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	Provedor de dados J. Venom. Anim. Toxins incl. Trop. Dis. (2) Autor Chen,J (2) Wei,CB (2) Li,JH (1) Palavra-chave Acutolysin C (1) Agkistrodon acutus (1) CDNA library (1) Deinagkistrodon acutus (1) Gene expression pattern analysis (1) Hemorrhagin (1) Leucoagglutination activity (1) Lipocalin (1) Phylogeny (1) Mais... Tipo do documento Info:eu-repo/semantics/article (2) Ano 2012 (1) 2011 (1) País Brazil (2) Idioma Inglês (2)		Ordenar por:  Relevância Autor Título Ano Registros recuperados: 2 Primeira ... 1 ... Última A novel lipocalin homologue from the venom gland of Deinagkistrodon acutus similar to mammalian lipocalins J. Venom. Anim. Toxins incl. Trop. Dis. Wei,CB; Chen,J. Lipocalins are involved in a variety of functions including retinol transport, cryptic coloration, olfaction, pheromone transport, prostaglandin synthesis, regulation of the immune response and cell homeostatic mediation. A full-length cDNA clone (named d-lipo), isolated from the venom gland cDNA library of Deinagkistrodon acutus, contained an insert of 664 bp including an open reading frame that encodes a lipocalin homologue of 177 amino acids. Comparison of d-lipo and other related proteins revealed an overall amino acid identity of less than 21.5%. Primary structures of d-lipo carried three structurally conserved regions (SCR) showing homologies to those of lipocalins. The first conserved Cys residue - the essential amino acid residue for the catalytic... Tipo: Info:eu-repo/semantics/article Palavras-chave: Deinagkistrodon acutus; CDNA library; Lipocalin; Phylogeny; Gene expression pattern analysis. Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992012000100003 Acutolysin C, a weak hemorrhagic toxin from the venom of Agkistrodon acutus with leucoagglutination activity J. Venom. Anim. Toxins incl. Trop. Dis. Wei,CB; Chen,J; Li,JH. The properties and agglutination activity of acutolysin C, a hemorrhagic metalloproteinase obtained from Agkistrodon acutus venom, were studied herein. Acutolysin C is a basic glycoprotein consisting of a single polypeptide chain with a molecular weight of 23.1 kDa and pI 8.7, containing one Zn2+ and one Ca²+ per molecule. It possesses caseinolytic, weak lethal (LD50 = 7.6 mg/kg) and weak hemorrhagic (MHD = 12.0 μg) activities, but does not present fibrinolytic, fibrinogenolytic, arginine esterase and phospholipase A2 actions. In addition, it revealed agglutination activity on some animal lymphocytes, including five species of mammals, six of birds, three of reptiles and one of amphibians, but had no effect on lymphocytes from two species of reptiles, one... Tipo: Info:eu-repo/semantics/article Palavras-chave: Agkistrodon acutus; Acutolysin C; Hemorrhagin; Leucoagglutination activity. Ano: 2011 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992011000100005 Registros recuperados: 2 Primeira ... 1 ... Última

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